rs10100651 - INTS8

Magnitude 2.0 · 1 study on file

Reported associations

• Multivariate genome-wide analysis of stress-related quantitative phenotypes. - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (2020) · Schijven D, Geuze E, Vinkers CH, Pulit SL, Schür RR, Malgaz M, Bekema E, Medic J, van der Kust KE, Veldink JH, Boks MP, Vermetten E, Luykx JJ · PubMed 31606302

  Exposure to traumatic stress increases the odds of developing a broad range of psychiatric conditions. Genetic studies targeting multiple stress-related quantitative phenotypes may shed light on mechanisms underlying vulnerability to psychopathology in the aftermath of stressful events. We applied a multivariate genome-wide association study (GWAS) to a unique military cohort (N = 583) in which we measured biochemical and behavioral phenotypes. The availability of pre- and post-deployment measurements allowed to capture changes in these phenotypes in response to stress. For genome-wide significant loci, we performed functional annotation, phenome-wide analysis and quasi-replication in PTSD case-control GWASs. We discovered one genetic variant reaching genome-wide significant associatio

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