rs10099237 - RGS22
Magnitude 2.8 · 1 study on file
Reported associations
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Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure - Unknown journal (n.d.) · Unknown authors · PubMed 29739929
ABSTRACT: The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with pigmentation-related phenotypes. Our results also suggest that variants at the AHR/AGR3 locus, previously associated with cutaneous malignant melanoma the underlying mechanism of which is poorly understood, might act on disease risk through modulation of tanning ability. The skin's tanning response to sun exposure shows great interindividual variability. Here, Visconti
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Year-round photoprotection Moderate
Genetic predisposition to non-melanoma skin cancer identified; UV exposure is the primary modifiable risk factor
Daily broad-spectrum sunscreen (SPF 30+), protective clothing (UPF 50+), avoid peak sun 10am-4pm
Screening
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Annual dermatological skin examination Moderate
rs10099237-C allele is associated with 1.22-fold increased non-melanoma skin cancer risk per allele
Annual full-body skin screening by dermatologist