rs10096872 - XKR6
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide characterization of circulating metabolic biomarkers - Unknown journal (n.d.) · Unknown authors · PubMed 38448586
ABSTRACT: Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases. Here we present a genome-wide association study for 233 circulating metabolic traits quantified by nuclear magnetic resonance spectroscopy in up to 136,016 participants from 33 cohorts. We identify more than 400 independent loci and assign probable causal genes at two-thirds of these using manual curation of plausible biological candidates. We highlight the importance of sample and participant characteristics that can have significant effects on genetic associa
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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lipid panel with VLDL composition Moderate
rs10096872 T allele associated with increased cholesterol in large and medium VLDL particles, indicating altered lipid metabolism.
Baseline lipid panel including VLDL subfraction analysis; repeat annually or per physician guidance.
Discuss with your doctor
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lipid management strategy given genetic marker Moderate
Genetic association with elevated VLDL cholesterol warrants personalized lipid management planning.