rs1009628 - RNF126
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic Association of Finger Photoplethysmography-Derived Arterial Stiffness Index with Blood Pressure and Coronary Artery Disease - Unknown journal (n.d.) · Unknown authors · PubMed 31070453
ABSTRACT: Objective: Arterial stiffness index (ASI) is independently associated with blood pressure and coronary artery disease (CAD) epidemiologically. However, it is unknown whether these associations represent causal relationships. Here, we assess whether genetic predisposition to increased ASI is associated with elevated blood pressure and CAD risk. Approach and Results: We first performed a large-scale epidemiologic association of finger photoplethysmography-derived ASI in the UK Biobank, finding significant associations with systolic blood pressure (SBP; Beta 0.55mmHg, [95% CI, 0.45-0.65], P=5.77×10−24, N=137,858), diastolic blood pressure (DBP; Beta 1.05mmHg, [95% CI, 0.99-1.11], P=7.27×10−272, N=137,862), and incident CAD (HR 1.08 [95% CI, 1.04-1.11], P=1.5×10−6; N=3
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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Vegetable intake Low
Higher vegetable consumption is epidemiologically associated with lower arterial stiffness
Aim for at least 6 tablespoons per day
Exercise
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Regular aerobic exercise Moderate
Aerobic exercise is strongly epidemiologically associated with lower arterial stiffness independent of other risk factors
Maintain at least 3 hours per week of moderate to vigorous aerobic activity
Screening
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Blood pressure monitoring Moderate
Genetic predisposition to elevated arterial stiffness through RNF126 causally predicts higher blood pressure per Mendelian randomization
Check blood pressure at least annually