Expressive

rs10095782 - CDCA2 - EBF2

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • hernia risk and prevention strategies Moderate

    Genetic predisposition warrants personalized discussion of screening and preventive approaches.

Exercise

  • strenuous lifting and heavy exertion Moderate

    Heavy lifting and abdominal straining increase intra-abdominal pressure, a modifiable risk factor for hernia formation.

    Avoid competitive weightlifting and repetitive heavy lifting; use proper body mechanics when lifting.

Lifestyle

  • weight management Moderate

    Obesity increases intra-abdominal pressure and mechanical stress on the abdominal wall, elevating hernia risk.

    Maintain healthy BMI; consult healthcare provider for personalized weight management target.

Screening

  • inguinal hernia symptoms Moderate

    Genetic predisposition increases lifetime hernia risk; early detection enables timely intervention.

    Be aware of groin lump, pain, or discomfort; seek medical evaluation if symptoms develop.