rs10094888 - LYPD2 - LYNX1-SLURP2
Magnitude 2.2 · 1 study on file
Reported associations
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The genetic basis of dermatophytosis skin infection susceptibility - Unknown journal (n.d.) · Unknown authors · PubMed 41792138
ABSTRACT: Dermatophytosis is a fungal infection affecting keratinized tissues such as skin, nails, and hair, presenting as red and itchy patches, nail thickening, or hair loss. It affects around 20% of the global population but the genetic architecture remains poorly understood. We performed a genome-wide association meta-analysis of over 250,000 cases and 1.37 million controls from FinnGen, Estonian Biobank, UK Biobank, and the Million Veteran Program and identified 30 genome-wide significant loci, including seven missense variants and two loci in high linkage disequilibrium with missense variants. Top associations were near ZNF646, HLA-DQB1, FLG, FTO, SLURP2, and KRT77. Additionally, dermatophytosis subtype analyses revealed 44 signals. Our results highlight the role of disrupted keratin
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Maintain strict foot hygiene to reduce infection risk Moderate
Dermatophytes exploit skin barrier compromise; dry environment and proper foot care reduce spore germination and colonization
Dry feet thoroughly after bathing; change socks if damp; use breathable footwear; trim nails
Screening
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Screen regularly for dermatophyte infection High
T allele at rs10094888 increases dermatophytosis risk through altered SLURP2/LYNX1 expression affecting skin barrier and immune function
Check feet and nails monthly for scaling or discoloration; annual dermatology screening