rs10092633 - SFRP1

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males - Unknown journal (n.d.) · Unknown authors · PubMed 30431558

  ABSTRACT: Supplemental Digital Content is Available in the Text. A polymorphic locus associated with a protective effect against painful temporomandibular disorder in males regulates the expression of the muscle RAS oncogene homolog (MRAS) gene. Abstract Painful temporomandibular disorders (TMDs) are the leading cause of chronic orofacial pain, but its underlying molecular mechanisms remain obscure. Although many environmental factors have been associated with higher risk of developing painful TMD, family and twin studies support a heritable genetic component as well. We performed a genome-wide association study assuming an additive genetic model of TMD in a discovery cohort of 999 cases and 2031 TMD-free controls from the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA)

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