rs10090615 - CSGALNACT1 - INTS10
Magnitude 2.2 · 1 study on file
Reported associations
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Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome - Unknown journal (n.d.) · Unknown authors · PubMed 39349817
ABSTRACT: Metabolic syndrome (MetS) is a complex hereditary condition comprising various metabolic traits as risk factors. Although the genetics of individual MetS components have been investigated actively through large-scale genome-wide association studies, the conjoint genetic architecture has not been fully elucidated. Here, we performed the largest multivariate genome-wide association study of MetS in Europe (nobserved = 4,947,860) by leveraging genetic correlation between MetS components. We identified 1,307 genetic loci associated with MetS that were enriched primarily in brain tissues. Using transcriptomic data, we identified 11 genes associated strongly with MetS. Our phenome-wide association and Mendelian randomization analyses highlighted associations of MetS with diverse di
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Annual metabolic and lipid panel Moderate
Metabolic syndrome risk variant warrants regular monitoring of glucose, lipids, and insulin resistance markers
Annual fasting glucose, triglycerides, HDL cholesterol, and lipid panel; consider HbA1c every 2-3 years
Discuss with your doctor
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Metabolic syndrome risk and prevention strategies Moderate
Genetic predisposition identified; discussion allows for personalized prevention and monitoring plans
Screening
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Baseline metabolic syndrome assessment Moderate
rs10090615 variant associated with increased metabolic syndrome risk (p=1.00e-11, n=1384348)
Screen for waist circumference, blood pressure, triglyceride and glucose levels, HDL cholesterol