rs10090288 - MICU3

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study of comorbid depressive syndrome and alcohol dependence - Unknown journal (n.d.) · Unknown authors · PubMed 22064162

  ABSTRACT: Objective Depression and alcohol dependence are common psychiatric disorders that often co-occur. Both disorders are genetically influenced, with heritability estimates in the range of 35-60%. In addition, evidence from twin studies suggests that alcohol dependence and depression are genetically correlated. Here we report results from a genome-wide association study (GWAS) of a comorbid phenotype in which cases meet the DSM-IV symptom threshold for major depressive symptomatology and DSM-IV criteria for alcohol dependence. Methods Samples (N=467 cases and N=407 controls) were of European-American descent, and were genotyped using the Illumina Human 1M BeadChip array. Results Although no SNP meets genome-wide significance criteria, we identify ten markers with p-values < 1 × 10

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