rs10083777 - CENPN, CENPN-AS1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA - Unknown journal (n.d.) · Unknown authors · PubMed 27005778

  ABSTRACT: Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive molecular profiling of circulating metabolites captures highly heritable traits, which can help to uncover metabolic pathophysiology underlying established disease variants. We conduct an extended genome-wide association study of genetic influences on 123 circulating metabolic traits quantified by nuclear magnetic resonance metabolomics from up to 24,925 individuals and identify eight novel loci for amino acids, pyruvate and fatty acids. The LPA locus link with cardiovascular risk exemplifies how detailed metabolic profiling may inform underlying aetiology via extensive associations with very-low-density lipoprotein a

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