Expressive

rs10083386 - PROX2 - DLST

Magnitude 2.2 · 2 studies on file

Reported associations

  • Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci - Unknown journal (n.d.) · Unknown authors · PubMed 27618448

    ABSTRACT: Meta-analyses of association results for blood pressure using exome-centric single-variants and gene-based tests identified 31 novel loci in discovery among 146,562 individuals with follow-up and meta-analysis in 180,726 additional individuals (Ntotal=327,288). These blood pressure loci are enriched for known cardiometabolic trait variants. Associations were also observed for the aggregation of rare/low-frequency missense variants in three genes, NPR1, DBH, and PTPMT1. In addition, blood pressure associations at 39 previously reported loci were confirmed. The identified variants implicate biological pathways related to cardiometabolic traits, vascular function, and development. Several new variants are inferred to have roles in transcription or as hubs in protein-protein interact

  • Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals - Unknown journal (n.d.) · Unknown authors · PubMed 33230300

    ABSTRACT: Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency, MAF > 0.05). In a meta-analysis of up to >1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (MAF ≤ 0.01) variant BP associations (P < 5 × 10-8), of which 32 were in new BP-associated loci and 55 were independent BP-associated SNVs within known BP-associated regions. Average effects of rare variants (44% coding) were ~8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (e.g. GATA5, PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. M

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • limit sodium intake Moderate

    Dietary sodium reduction attenuates blood pressure elevation in genetically susceptible individuals

    Limit to less than 2,300 mg sodium daily; ideally 1,500 mg

Discuss with your doctor

  • hypertension prevention strategy Moderate

    Early identification of genetic hypertension risk enables prevention planning and medication optimization if needed

    Discuss cardiovascular risk management at next appointment

Exercise

  • aerobic exercise Moderate

    Regular aerobic exercise reduces blood pressure through improved endothelial function and vascular compliance

    150 minutes moderate-intensity or 75 minutes vigorous-intensity aerobic activity per week

Screening

  • blood pressure monitoring High

    rs10083386 risk allele A increases systolic and mean arterial pressure; monitoring enables early detection and intervention

    Annual screening; more frequently if baseline is elevated