Expressive

rs10080150 - CEP72-DT

Magnitude 2.2 · 1 study on file

Reported associations

  • Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis - Unknown journal (n.d.) · Unknown authors · PubMed 34187846

    ABSTRACT: Objective Gastro-oesophageal reflux disease (GERD) has heterogeneous aetiology primarily attributable to its symptom-based definitions. GERD genome-wide association studies (GWASs) have shown strong genetic overlaps with established risk factors such as obesity and depression. We hypothesised that the shared genetic architecture between GERD and these risk factors can be leveraged to (1) identify new GERD and Barrett's oesophagus (BE) risk loci and (2) explore potentially heterogeneous pathways leading to GERD and oesophageal complications. Design We applied multitrait GWAS models combining GERD (78 707 cases; 288 734 controls) and genetically correlated traits including education attainment, depression and body mass index. We also used multitrait analysis to identify BE ri

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Barrett's esophagus screening considerations High

    rs10080150 carries strong genetic risk for Barrett's esophagus (p=1.00e-9), a precancerous esophageal condition arising from chronic GERD-induced metaplasia.

    Discuss with gastroenterologist; screening endoscopy may be considered if additional GERD risk factors present.

Lifestyle

  • Weight management for GERD control Moderate

    rs10080150 operates through an obesity-driven GERD axis; weight reduction decreases intra-abdominal pressure and reflux burden, reducing Barrett's progression risk.

    Maintain BMI <25 kg/m2 or achieve 5-10% weight loss if overweight through sustained diet and exercise changes.