rs10076733 - LINC02863, CARINH
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell type and phenotype associations - Unknown journal (n.d.) · Unknown authors · PubMed 30804561
ABSTRACT: Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide novel insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci with P-value < 5 × 10−8; 47 were previously described in association with either COPD or population-based lung function. Of the remaining 35 novel loci, 13 were associated with lung function in 79,055 individuals from the SpiroMeta consortium. Using gene expression and regulation data, we identified enrichment for loci in lung tissue, smooth muscle and several lung cell types. We found 14 COPD loci shared with either
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Occupational and environmental lung irritants Moderate
Genetic predisposition to COPD; exposure to air pollutants and irritants poses elevated risk for carriers of this variant.
Use respiratory protection when occupational exposure unavoidable; maintain good indoor air quality
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Smoking and secondhand smoke exposure Moderate
Genetic predisposition to COPD substantially increases harm from smoking exposure; airway protection critical for risk carriers.
Complete smoking cessation if current user; avoid secondhand smoke exposure
Screening
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COPD screening and spirometry Moderate
rs10076733 (LINC02863) associated with chronic obstructive pulmonary disease in large GWAS; baseline respiratory assessment recommended for genetic risk carriers.
Discuss baseline spirometry with physician, especially if age >40 or occupational/environmental exposure history