rs1007365 - RASGRF1
Magnitude 2.2 · 1 study on file
Reported associations
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Insights into the genetic basis of retinal detachment - Unknown journal (n.d.) · Unknown authors · PubMed 31816047
ABSTRACT: Abstract Retinal detachment (RD) is a serious and common condition, but genetic studies to date have been hampered by the small size of the assembled cohorts. In the UK Biobank data set, where RD was ascertained by self-report or hospital records, genetic correlations between RD and high myopia or cataract operation were, respectively, 0.46 (SE = 0.08) and 0.44 (SE = 0.07). These correlations are consistent with known epidemiological associations. Through meta-analysis of genome-wide association studies using UK Biobank RD cases (N = 3 977) and two cohorts, each comprising ~1 000 clinically ascertained rhegmatogenous RD patients, we uncovered 11 genome-wide significant association signals. These are near or within ZC3H11B, BMP3, COL22A1, DLG5, PLCE1, EFEMP2, TYR, F
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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regular ophthalmologic assessment for myopia Moderate
RASGRF1 genetic variants confer substantially elevated risk for high myopia development
baseline assessment and periodic ophthalmologic exams, especially in childhood and adolescence