rs10071234 - MEF2C-AS1

Magnitude 2.0 · 1 study on file

Reported associations

• Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia. - Nature human behaviour (2025) · Dang X, Teng Z, Yang Y, Li W, Liu J, Hui L, Zhou D, Gong D, Dai SS, Li Y, Li X, Lv L, Zeng Y, Yuan Y, Ma X, Liu Z, Li T, Luo XJ · PubMed 39753749

  Genome-wide association studies (GWASs) have reported multiple risk loci for schizophrenia (SCZ). However, the majority of the associations were from populations of European ancestry. Here we conducted a large-scale GWAS in Eastern Asian populations (29,519 cases and 44,392 controls) and identified ten Eastern Asian-specific risk loci, two of which have not been previously reported. A further cross-ancestry GWAS meta-analysis (96,806 cases and 492,818 controls) including populations from diverse ancestries identified 61 previously unreported risk loci. Systematic variant-level analysis, including fine mapping, functional genomics and expression quantitative trait loci, prioritized potential causal variants. Gene-level analyses, including transcriptome-wide association study, proteome-wide

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