rs10069027 - LINC02215 - RNU7-34P

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide admixture and association study of subclinical atherosclerosis in the Women's Interagency HIV Study (WIHS) - Unknown journal (n.d.) · Unknown authors · PubMed 29206233

    ABSTRACT: Cardiovascular disease (CVD) is a major comorbidity among HIV-infected individuals. Common carotid artery intima-media thickness (cCIMT) is a valid and reliable subclinical measure of atherosclerosis and is known to predict CVD. We performed genome-wide association (GWA) and admixture analysis among 682 HIV-positive and 288 HIV-negative Black, non-Hispanic women from the Women's Interagency HIV study (WIHS) cohort using a combined and stratified analysis approach. We found some suggestive associations but none of the SNPs reached genome-wide statistical significance in our GWAS analysis. The top GWAS SNPs were rs2280828 in the region intergenic to mediator complex subunit 30 and exostosin glycosyltransferase 1 (MED30 | EXT1) among all women, rs2907092 in the catenin delta 2 (CT


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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Screening

  • cardiovascular risk assessment Moderate

    The T allele at rs10069027 is associated with increased carotid intima-media thickness, a marker of atherosclerotic burden and cardiovascular disease risk