Expressive

rs1006899 - HSPA13 - SAMSN1

Magnitude 2.2 · 1 study on file

Reported associations

  • New sequence variants associated with bone mineral density. - Nature genetics (2009) · Styrkarsdottir U, Halldorsson BV, Gretarsdottir S, Gudbjartsson DF, Walters GB, Ingvarsson T, Jonsdottir T, Saemundsdottir J, Snorradóttir S, Center JR, Nguyen TV, Alexandersen P, Gulcher JR, Eisman JA, Christiansen C, Sigurdsson G, Kong A, Thorsteinsdottir U, Stefansson K · PubMed 19079262

    In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • dietary calcium intake Moderate

    SNP-associated BMD variation indicates bones may be responsive to nutritional optimization; calcium is essential for bone strength.

    Aim for 1000-1200 mg daily from food sources; meet via dairy, leafy greens, fortified foods.

Discuss with your doctor

  • genetic findings related to bone health Moderate

    SNP rs1006899 has highly significant association with spine bone mineral density (p<0.000001); physician guidance can personalize management.

Exercise

  • weight-bearing exercise Moderate

    Mechanical loading of bone stimulates adaptation; particularly relevant given this SNP's significant association with BMD.

    150 minutes per week of moderate-intensity weight-bearing exercise (walking, jogging, dancing, or resistance training).

Screening

  • bone mineral density (DEXA scan) Moderate

    This SNP is significantly associated with spine bone mineral density variation; monitoring establishes baseline and tracks changes.

    Discuss baseline screening with healthcare provider; repeat every 1-2 years or per provider recommendation.

Supplements

  • vitamin D supplementation Moderate

    Vitamin D enables calcium absorption and is critical for bone health; particularly relevant with SNP-associated BMD variation.

    1000-2000 IU daily; consider testing 25-hydroxyvitamin D levels.