rs10068315 - EPB41L4A
Magnitude 2.8 · 1 study on file
Reported associations
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Gene polymorphisms associated with heterogeneity and senescence characteristics of sarcopenia in chronic obstructive pulmonary disease - Unknown journal (n.d.) · Unknown authors · PubMed 36856146
ABSTRACT: Abstract Background Sarcopenia, or loss of skeletal muscle mass and decreased contractile strength, contributes to morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD). The severity of sarcopenia in COPD is variable, and there are limited data to explain phenotype heterogeneity. Others have shown that COPD patients with sarcopenia have several hallmarks of cellular senescence, a potential mechanism of primary (age‐related) sarcopenia. We tested if genetic contributors explain the variability in sarcopenic phenotype and accelerated senescence in COPD. Methods To identify gene variants [single nucleotide polymorphisms (SNPs)] associated with sarcopenia in COPD, we performed a genome‐wide association study (GWAS) of fat free mass index (FFMI) in
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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adequate dietary protein Moderate
Adequate protein intake supports muscle maintenance against sarcopenia risk conferred by EPB41L4A variants
target 1.2 to 1.5 g per kg body weight daily
Exercise
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resistance training Moderate
Muscle strengthening through resistance exercise helps offset the genetic predisposition to sarcopenia associated with EPB41L4A risk alleles
2-3 sessions per week targeting major muscle groups
Screening
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sarcopenia screening or assessment Moderate
EPB41L4A risk allele rs10068315 is associated with sarcopenia in COPD patients, indicating increased genetic predisposition to muscle mass loss
baseline skeletal muscle mass assessment, consider hand-grip strength testing