rs10067798 - TENM2

Magnitude 2.0 · 2 studies on file

Reported associations

• Genetic determinants of childhood blood pressure and heart rate in relation to adult health outcomes: the consortium of childhood blood pressure. - European heart journal (2026) · Xie T, Ani A, Vaez A, Nolte IM, Su S, Ishikuro M, Wang S, Zhang W, Soares AG, Motazedi E, Calas L, Ronkainen J, Pedersen CT, Lu X, Stinson SE, Felix JF, Stankevic E, Wang CA, Thiering E, Fernández D, Calvo-Serra B, Stathopoulou MG, Fore R, Kumar A, Tuhkanen J, Bilbao JR, Ibarluzea J, Isaacs A, Fonvig CE, Rivadeneira F, Lund MAV, Holm LA, van der Most PJ, Riese H, Narita A, Tamiya G, Flexeder C, Wiersma R, Argoty-Pantoja AD, Vinding R, Hansen TW, Kümler T, Estarlich M, Bustamante M, Yuan WL, Boland-Augé A, Deleuze JF, Petrelis AM, Rifas-Shiman S, Kajantie E, Fernandez-Jimenez N, Santa-Marina L, Arts ICW, Lahti J, Strandberg T, Kull I, Bergström A, Hivert MF, Bønnelykke K, Kuriyama S, Beilin LJ, Mori TA, Hartman CA, Grarup N, Thijs C, Räikkönen K, Melén E, Oken E, Visvikis-Siest S, Gützkow KB, Grazuleviciene R, Heude B, Chatzi L, Vrijheid M, Standl M, Vrijkotte T, Pennell CE, Oldehinkel AJ, Hansen T, Jaddoe VWV, Holm JC, Sebert S, Timpson NJ, Obara T, Wang X, Lawlor DA, Corpeleijn E, Ahluwalia TS, Snieder H · PubMed 42036355

  To elucidate the genetic architecture of blood pressure (BP) and heart rate (HR) during early life and assess their potential relevance to adult health outcomes. The largest genome-wide association study (GWAS) meta-analyses to date of childhood systolic BP, diastolic BP, pulse pressure, and mean arterial pressure (n = 28 425) and HR (n = 22 565) were conducted in children of European ancestry aged 4-17 years. Follow-up analyses included comparisons with adult GWAS results, polygenic risk score (PRS) analyses in independent cohorts of diverse ancestries, and a phenome-wide association study in the UK Biobank. Eight genome-wide significant loci were identified for childhood BP (KIAA2013, CACNB2, PLCE1, PAX2, COL4A2, RP11-236L14.1, CFDP1, TPX2) and three loci for childhood HR (CCDC141, ACHE,

• Leveraging Polygenic Functional Enrichment to Improve GWAS Power. - American journal of human genetics (2019) · Kichaev G, Bhatia G, Loh PR, Gazal S, Burch K, Freund MK, Schoech A, Pasaniuc B, Price AL · PubMed 30595370

  Functional genomics data has the potential to increase GWAS power by identifying SNPs that have a higher prior probability of association. Here, we introduce a method that leverages polygenic functional enrichment to incorporate coding, conserved, regulatory, and LD-related genomic annotations into association analyses. We show via simulations with real genotypes that the method, functionally informed novel discovery of risk loci (FINDOR), correctly controls the false-positive rate at null loci and attains a 9%-38% increase in the number of independent associations detected at causal loci, depending on trait polygenicity and sample size. We applied FINDOR to 27 independent complex traits and diseases from the interim UK Biobank release (average N = 130K). Averaged across traits, we attaine

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