rs10065798 - DMGDH

Magnitude 2.2 · 1 study on file

Reported associations

• Unraveling interindividual variation of trimethylamine N‐oxide and its precursors at the population level Unraveling Interindividual Variation of Trimethylamine N‐Oxide and its Precursors at the Population Level - Unknown journal (n.d.) · Unknown authors · PubMed 38898991

  ABSTRACT: Abstract Trimethylamine N‐oxide (TMAO) is a circulating microbiome‐derived metabolite implicated in the development of atherosclerosis and cardiovascular disease (CVD). We investigated whether plasma levels of TMAO, its precursors (betaine, carnitine, deoxycarnitine, choline), and TMAO‐to‐precursor ratios are associated with clinical outcomes, including CVD and mortality. This was followed by an in‐depth analysis of their genetic, gut microbial, and dietary determinants. The analyses were conducted in five Dutch prospective cohort studies including 7834 individuals. To further investigate association results, Mendelian Randomization (MR) was also explored. We found only plasma choline levels (hazard ratio [HR] 1.17, [95% CI 1.07; 1.28]) and not TMAO to be associated wit

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