Expressive

rs1006437246 - SMIM30 - PPP1R3A

Magnitude 2.2 · 1 study on file

Reported associations

  • A cross-population atlas of genetic associations for 220 human phenotypes. - Nature genetics (2021) · Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A, Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y · PubMed 34594039

    Current genome-wide association studies do not yet capture sufficient diversity in populations and scope of phenotypes. To expand an atlas of genetic associations in non-European populations, we conducted 220 deep-phenotype genome-wide association studies (diseases, biomarkers and medication usage) in BioBank Japan (n = 179,000), by incorporating past medical history and text-mining of electronic medical records. Meta-analyses with the UK Biobank and FinnGen (n = 628,000) identified ~5,000 new loci, which improved the resolution of the genomic map of human traits. This atlas elucidated the landscape of pleiotropy as represented by the major histocompatibility complex locus, where we conducted HLA fine-mapping. Finally, we performed statistical decomposition of matrices of phenome-wid

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • genetic predisposition to sleep apnea syndrome Moderate

    GWAS association indicates elevated baseline risk; enables coordinated screening and personalized management

Exercise

  • regular aerobic exercise Moderate

    improves sleep quality and supports weight management, both protective against apnea development

    150 minutes moderate-intensity aerobic activity per week

Lifestyle

  • limit alcohol and sedative medications Moderate

    alcohol and sedatives relax pharyngeal muscles, worsening apnea; particularly relevant with genetic predisposition

  • preferential side sleeping via positional therapy Moderate

    side sleeping reduces upper airway obstruction; beneficial with genetic apnea predisposition

    use positional device or avoid supine sleep

  • weight management if overweight Moderate

    weight is primary modifiable risk factor for sleep apnea; weight loss reduces severity with genetic predisposition

    maintain BMI 18.5-24.9 kg/m2

Screening

  • sleep apnea screening Moderate

    genetic predisposition increases sleep apnea syndrome risk; early detection enables appropriate management

    polysomnography or home sleep apnea test