rs10063311 - FST - NDUFS4

Magnitude 2.2 · 1 study on file

Reported associations

• Nuclear genome-wide associations with mitochondrial heteroplasmy - Unknown journal (n.d.) · Unknown authors · PubMed 33731350

  ABSTRACT: This study identifies regions of the nuclear genome that affect heteroplasmy, the mixture of different mitochondrial DNA. The role of the nuclear genome in maintaining the stability of the mitochondrial genome (mtDNA) is incompletely known. mtDNA sequence variants can exist in a state of heteroplasmy, which denotes the coexistence of organellar genomes with different sequences. Heteroplasmic variants that impair mitochondrial capacity cause disease, and the state of heteroplasmy itself is deleterious. However, mitochondrial heteroplasmy may provide an intermediate state in the emergence of novel mitochondrial haplogroups. We used genome-wide genotyping data from 982,072 European ancestry individuals to evaluate variation in mitochondrial heteroplasmy and to identify the regions o

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