rs10060613 - FAT2

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic Variants and Polygenic Risk Scores Linked to Atopic Dermatitis Risk, Severity, and Serum IgE Levels. - Experimental dermatology (2025) · Wei CC, Liao WL, Lu HF, Yang JS, Chang YY, Yong SB, Chen HY, Wang JY, Tsai FJ · PubMed 41376111

  Atopic dermatitis (AD) is a chronic inflammatory skin disease with high heritability, yet its genetic basis, especially in non-European populations, is not fully elucidated. To identify genetic variants associated with AD and to evaluate polygenic risk scores (PRS) for predicting AD risk, severity, and serum IgE levels in a Taiwanese Han population. We conducted a genome-wide association study (GWAS) using data from the China Medical University Hospital Biobank (1031 AD cases, 2106 controls). Two PRS models were developed: PRS_AD (AD risk) and PRS_IgE (IgE levels). The cohort was split into discovery and replication sets (8:2 ratio). Logistic regression, adjusted for age, sex, and population stratification, was used. The GWAS identified a novel AD-associated locus: rs905307 in RANBP2 (OR

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