rs10059921 - TMEM161B
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk - Unknown journal (n.d.) · Unknown authors · PubMed 28135244
ABSTRACT: Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. Combined with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine appr
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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cardiovascular risk assessment Moderate
Genetic predisposition to elevated systolic blood pressure through TMEM161B-associated pathways in arterial and adipose tissue
Screening
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blood pressure Moderate
T allele at rs10059921 associated with higher systolic blood pressure in 140,882-person GWAS (effect 0.526 mmHg, p=4.00e-9)
check annually, more frequently if readings borderline elevated