rs10057501 - SDHA

Magnitude 2.0 · 1 study on file

Reported associations

• Deciphering tissue-specific protein regulation for insights into cardiometabolic disease - Molecular metabolism (2026) · Hartley AE, Sukhavasi K, Hu S, Traylor M, Gonzalez-Ramirez M, Hanghøj KE, Talukdar H, Ruusalepp A, Björkegren E, Björkegren JL, Howson JM, Jamshidi Y · PubMed 41456820

  ABSTRACT: Understanding tissue-specific mechanisms of protein regulation gives crucial insights into cardiometabolic disease and informs drug discovery. Most proteomic studies have primarily concentrated on plasma, overlooking tissue-specific effects. Utilizing Olink technology, we assessed relative protein levels across plasma and tissue (aortic wall, mammary artery, liver, and skeletal muscle) from the STARNET cohort: 284 individuals with a high prevalence of coronary artery disease (CAD). We identified 608 cis protein quantitative trait loci (pQTLs), primarily in plasma, reflecting greater protein variability. Of 190 proteins with cis-pQTLs in non-plasma tissues, 50% also had plasma pQTLs, validating Olink technology in these tissues while reinforcing the relevance of plasma data for un

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