Expressive

rs10052777 - EBF1

Magnitude 2.2 · 1 study on file

Reported associations

  • High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 35762941

    ABSTRACT: Purpose To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. Methods Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics. Results Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per 10-mm Hg inc

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • excessive sodium intake Moderate

    High sodium increases blood pressure and pulse pressure through fluid and vascular effects

    Maintain <2300 mg per day; ideally <1500 mg for cardiovascular benefit

Discuss with your doctor

  • cardiovascular risk assessment and management Moderate

    EBF1 variant affects pulse pressure; discussion clarifies individual risk and management

Exercise

  • regular aerobic exercise Moderate

    Aerobic exercise improves arterial compliance and reduces vascular stiffness

    150 minutes per week of moderate-intensity aerobic activity

Lifestyle

  • weight optimization and stress management Moderate

    Obesity and chronic stress increase vascular stiffness and pulse pressure

    Maintain BMI <25 kg/m2; practice daily stress reduction

Screening

  • blood pressure and pulse pressure screening Moderate

    EBF1 rs10052777 T allele associated with increased pulse pressure, a marker of arterial stiffness

    Annual blood pressure check with pulse pressure calculation; more frequently if elevated