rs10047474 - GALNT18

Magnitude 4.5 · 1 study on file

Reported associations

• Identifying blood pressure loci whose effects are modulated by multiple lifestyle exposures. - Genetic epidemiology (2021) · Osazuwa-Peters OL, Waken RJ, Schwander KL, Sung YJ, de Vries PS, Hartz SM, Chasman DI, Morrison AC, Bierut LJ, Xiong C, de las Fuentes L, Rao DC · PubMed 32227373

  Although multiple lifestyle exposures simultaneously impact blood pressure (BP) and cardiovascular health, most analysis so far has considered each single lifestyle exposure (e.g., smoking) at a time. Here, we exploit gene-multiple lifestyle exposure interactions to find novel BP loci. For each of 6,254 Framingham Heart Study participants, we computed lifestyle risk score (LRS) value by aggregating the risk of four lifestyle exposures (smoking, alcohol, education, and physical activity) on BP. Using the LRS, we performed genome-wide gene-environment interaction analysis in systolic and diastolic BP using the joint 2 degree of freedom (DF) and 1 DF interaction tests. We identified one genome-wide significant (p < 5 × 10 ) and 11 suggestive (p < 1 × 10 ) loci. Gene-enviro

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