rs10046574 - CNOT4
Magnitude 4.5 · 1 study on file
Reported associations
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Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease - Unknown journal (n.d.) · Unknown authors · PubMed 27082954
ABSTRACT: There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, genome-scale investigations of these interactions have been rarely performed particularly in the case of air pollution exposures. We performed race-stratified genome-wide gene-environment interaction association studies on European-American (EA, N = 1623) and African-American (AA, N = 554) cohorts to investigate the joint influence of common single nucleotide polymorphisms (SNPs) and residential exposure to traffic ("traffic exposure")-a recognized vascular disease risk factor-on peripheral arterial disease (PAD). Traffic exposure was estimated via the dis
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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high-traffic air pollution exposure Moderate
Variant shows gene-environment interaction with traffic air pollution that increases PAD risk
minimize time on congested highways, use HEPA air filters indoors, avoid exercise during high pollution hours
Screening
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peripheral artery disease symptoms Moderate
CNOT4 rs10046574 variant associated with elevated PAD risk, particularly with traffic-related air pollution exposure
regular assessment for leg pain, weakness, or coolness during physical activity