rs10042968 - ISCA1P1 - HTR1A

Magnitude 2.8 · 1 study on file

Reported associations

• Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine co-dependence - Unknown journal (n.d.) · Unknown authors · PubMed 23216389

  ABSTRACT: Background Alcohol and nicotine co-dependence can be considered as a more severe subtype of alcohol dependence. A portion of its risk may be attributable to genetic factors. Methods We searched for significant risk genomic regions specific for this disorder using a genome-wide association study (GWAS). A total of 8,847 subjects underwent gene-disease association analysis, including (i) a discovery cohort of 818 European-American cases with alcohol and nicotine co-dependence and 1,396 European-American controls, (ii) a replication cohort of 5,704 Australian family subjects with 907 affected offspring, and (iii) a replication cohort of 449 African-American cases and 480 African-American controls. Additionally, a total of 38,714 subjects of European or African descent in 18 independ

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