rs10041935 - LINC02225 - LINC02101

Magnitude 2.2 · 2 studies on file

Reported associations

• Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. - Journal of the American Society of Nephrology : JASN (2015) · Chung SA, Brown EE, Williams AH, Ramos PS, Berthier CC, Bhangale T, Alarcon-Riquelme ME, Behrens TW, Criswell LA, Graham DC, Demirci FY, Edberg JC, Gaffney PM, Harley JB, Jacob CO, Kamboh MI, Kelly JA, Manzi S, Moser-Sivils KL, Russell LP, Petri M, Tsao BP, Vyse TJ, Zidovetzki R, Kretzler M, Kimberly RP, Freedman BI, Graham RR, Langefeld CD · PubMed 24925725

  Lupus nephritis is a manifestation of SLE resulting from glomerular immune complex deposition and inflammation. Lupus nephritis demonstrates familial aggregation and accounts for significant morbidity and mortality. We completed a meta-analysis of three genome-wide association studies of SLE to identify lupus nephritis-predisposing loci. Through genotyping and imputation, >1.6 million markers were assessed in 2000 unrelated women of European descent with SLE (588 patients with lupus nephritis and 1412 patients with lupus without nephritis). Tests of association were computed using logistic regression adjusting for population substructure. The strongest evidence for association was observed outside the MHC and included markers localized to 4q11-q13 (PDGFRA, GSX2; P=4.5×10(-7)), 16p12 (SLC5

• Genetic determinants of lung cancer prognosis in never smokers: A pooled analysis in the International Lung Cancer Consortium - Unknown journal (n.d.) · Unknown authors · PubMed 32699080

  ABSTRACT: Background: Lung cancer remains the leading cause of cancer death worldwide with 15-20% occurring in never-smokers. To assess genetic determinants for prognosis among never smokers, we conducted a genome-wide investigation in the International Lung Cancer Consortium(ILCCO). Methods: Genomic and clinical data from 1569 never-smoking lung cancer patients of European ancestry from 10 ILCCO studies were included. Hazard ratios(HRs) and 95% confidence intervals of overall survival were estimated. We assessed whether the associations were mediated through mRNA expression based 1553 normal lung tissues from the Lung expression quantitative trait loci(eQTL) dataset and GTEx. For cross-ethnicity generalization, we assessed the associations in a Japanese study(N=887). Results: One locus

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