rs10038774 - PIK3R1 - LINC02198
Magnitude 4.5 · 1 study on file
Reported associations
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Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 35884923
ABSTRACT: A comprehensive understanding of gene-diet interactions is necessary to establish proper dietary guidelines to prevent and manage cardio-cerebrovascular disease (CCD). We investigated the role of genetic variants associated with dyslipidaemia (DL) and their interactions with macro-nutrients for cardiovascular disease using a large-scale genome-wide association study of Korean adults. A total of 58,701 participants from a Korean genome and epidemiology study were included. Their dietary intake was assessed using a food frequency questionnaire. Dyslipidaemia was defined as total cholesterol (TCHL) ≥ 240 mg/dL, high-density lipoprotein (HDL) < 40 mg/dL, low-density lipoprotein (LDL) ≥ 160 mg/dL, triglycerides (TG) ≥ 200 mg/dL, or dyslipidaemia history. Their nutrient intake wa
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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Triglyceride levels Moderate
PIK3R1 rs10038774 C allele associated with elevated triglyceride levels in well-powered cohort.
Fasting lipid panel every 1-2 years
Diet
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Reduce refined carbohydrates and added sugars Moderate
PIK3R1 variant carriers have elevated triglycerides; refined carbs increase triglyceride production.
Reduce intake of sugary drinks and refined grains
Exercise
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Aerobic exercise Moderate
Regular aerobic exercise lowers triglycerides in genetically predisposed individuals.
Aim for 150 minutes moderate aerobic exercise weekly