rs10037124 - ATP10B

Magnitude 2.2 · 1 study on file

Reported associations

• Strong association between the 12q24 locus and sweet taste preference in the Japanese population revealed by genome-wide meta-analysis. - Journal of human genetics (2021) · Kawafune K, Hachiya T, Nogawa S, Takahashi S, Jia H, Saito K, Kato H · PubMed 32572145

  The sweet taste preference of humans is an important adaptation to ensure the acquisition of carbohydrate nutrition; however, overconsumption of sweet foods can potentially lead to diseases such as obesity and diabetes. Although previous studies have suggested that interindividual variation of human sweet taste preference is heritable, genetic loci associated with the trait have yet to be fully elucidated. Here, we genotyped 12,312 Japanese participants using the HumanCore-12+ Custom BeadChip or the HumanCore-24 Custom BeadChip microarrays. The sweet taste preference of the participants was surveyed via an internet-based questionnaire, resulting in a five-point scale of sweet taste preference. The genome-wide meta-analysis of the Japanese participants revealed a strong association between

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