rs10035449 - LINC03000

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways - Unknown journal (n.d.) · Unknown authors · PubMed 29662059

  ABSTRACT: Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the respective studies. Here, we conduct a genome-wide association study in 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification of Diseases (ICD, version 9 or 10)-coded MDD. We identify 17 independent loci that are significantly associated (P < 5 × 10−8) across the three phenotypes. The direction of effect of these loci is consistently replicated in an independent sample, with 14 loci likely representing novel findings. Gene sets are enriched in

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