rs10032519 - LINC00499
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study of metachronous colorectal adenoma risk among participants in the Selenium Trial - Unknown journal (n.d.) · Unknown authors · PubMed 35815403
ABSTRACT: Genetic variants related to colorectal adenoma may help identify those who are at highest risk of colorectal cancer development or illuminate potential chemopreventive strategies. The purpose of this genome-wide association study was to identify genetic variants that are associated with risk of developing a metachronous colorectal adenoma among 1,215 study participants of European descent from the Selenium Trial. Associations of variants were assessed with logistic regression analyses and validated in an independent case-control study population of 1,491 participants from the Colorectal Cancer Study of Austria (CORSA). No statistically significant genome-wide associations between any variant and metachronous adenoma were identified after correction for multiple comparisons. Howev
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Colorectal adenoma surveillance strategy Moderate
The C allele is associated with higher risk of advanced recurrent colorectal adenomas after polypectomy.
Discuss with gastroenterologist regarding surveillance strategy given increased adenoma recurrence risk