rs10031252 - UBA6-DT, GNRHR

Magnitude 2.2 · 1 study on file

Reported associations

• Elucidating the genetic basis of social interaction and isolation - Unknown journal (n.d.) · Unknown authors · PubMed 29970889

  ABSTRACT: The negative impacts of social isolation and loneliness on health are well documented. However, little is known about their possible biological determinants. In up to 452,302 UK Biobank study participants, we perform genome-wide association study analyses for loneliness and regular participation in social activities. We identify 15 genomic loci (P < 5 × 10−8) for loneliness, and demonstrate a likely causal association between adiposity and increased susceptibility to loneliness and depressive symptoms. Further loci were identified for regular attendance at a sports club or gym (N = 6 loci), pub or social club (N = 13) or religious group (N = 18). Across these traits there was strong enrichment for genes expressed in brain regions that control emotional exp

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