rs10029941 - AFAP1

Magnitude 2.2 · 1 study on file

Reported associations

• BIOMARKER AND GENOMIC RISK FACTORS FOR LIVER FUNCTION TEST ABNORMALITY IN HAZARDOUS DRINKERS - Unknown journal (n.d.) · Unknown authors · PubMed 30589442

  ABSTRACT: Background: Alcohol dependence and long-term excessive alcohol use may cause liver damage, but only some patients develop cirrhosis. Similarly, high alcohol intake without evident liver disease often but not always produces abnormal enzymatic liver function tests, particularly gamma-glutamyl transferase (GGT). We postulate that the factors predisposing to cirrhosis in alcoholics and to liver enzyme abnormality in drinkers are similar, and that biochemical liver function tests could therefore be useful as markers of risk of alcoholic liver disease in excessive drinkers. Methods: Data from participants in twin and twin-family studies on alcohol use and dependence were used to identify 1003 people who had reported excessive alcohol intake (28 drinks or more per week). 962 of these p

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