rs10029269 - LINC02462 - EEF1A1P35

Magnitude 2.0 · 1 study on file

Reported associations

• Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. - Carcinogenesis (2013) · Lee Y, Yoon KA, Joo J, Lee D, Bae K, Han JY, Lee JS · PubMed 23144319

  The prognostic significance of inherited genetic variants in advanced-stage non-small cell lung cancer (NSCLC) patients remains unknown. In this study, we genotyped 271 817 single-nucleotide polymorphisms in 348 advanced NSCLC patients who received chemotherapy and analyzed their association with prognosis by using Cox proportional hazard regression model adjusted for known prognostic factors. Top candidate single-nucleotide polymorphisms (SNPs) were selected using the bootstrap re-sampling procedure. Median age of patient population was 56 years. Proportions of female, never smokers and adenocarcinoma were 64.9, 67.5 and 80.4%, respectively. We identified 17 top candidate SNPs related to prognosis using cut-off minimum P value of <5.0 × 10(-5) in at least 70% of 1000 bootstrap samples. T

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