rs10027628 - PDLIM5 - BMPR1B-DT

Magnitude 4.5 · 1 study on file

Reported associations

• The Impact of Ancestry and Common Genetic Variants on QT Interval in African Americans - Unknown journal (n.d.) · Unknown authors · PubMed 23166209

  ABSTRACT: Background Ethnic differences in cardiac arrhythmia incidence have been reported, with a particularly high incidence of sudden cardiac death (SCD) and low incidence of atrial fibrillation in individuals of African ancestry. We tested the hypotheses that African ancestry and common genetic variants are associated with prolonged duration of cardiac repolarization, a central pathophysiological determinant of arrhythmia, as measured by the electrocardiographic QT interval. Methods and Results First, individual estimates of African and European ancestry were inferred from genome-wide single nucleotide polymorphism (SNP) data in seven population-based cohorts of African Americans (n=12 097) and regressed on measured QT interval from electrocardiograms. Second, imputation was performed

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