rs10026552 - UNC5C

Magnitude 2.0 · 1 study on file

Reported associations

• The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology - Communications biology (2026) · Moberget T, van der Meer D, Bahrami S, Roelfs D, Frei O, Kaufmann T, Fernandez-Cabello S, Kim M, Wolfers T, Diedrichsen J, Smeland OB, Shadrin A, Dale A, Andreassen OA, Westlye LT · PubMed 41703085

  ABSTRACT: The functional domain of the cerebellum has expanded beyond motor control to also include cognitive and affective functions. In line with this notion, cerebellar volume has increased over recent primate evolution, and cerebellar alterations have been linked to heritable mental disorders. To map the genetic architecture of human cerebellar morphology, we here studied a large imaging genetics sample from the UK Biobank (n discovery = 27,302; n replication: 11,264) with state-of-the art neuroimaging and biostatistics tools. Multivariate GWAS on regional cerebellar MRI features yielded 351 significant genetic loci (226 novel, 94% replicated). Lead SNPs showed positive enrichment for relatively recent genetic mutations over the last 20-40k years (i.e., overlapping the Upper Paleolithi

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