rs10024759 - ZNF827
Magnitude 2.8 · 1 study on file
Reported associations
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Genome‐wide association of individual vulnerability with alcohol‐associated liver disease: A Korean genome and epidemiology study - Unknown journal (n.d.) · Unknown authors · PubMed 34387878
ABSTRACT: Abstract Background and aims The quantity of alcohol leading to alcohol‐associated liver disease (ALD) varies individually. Genetic backgrounds contributing to the divergence in individual susceptibility to alcohol‐induced liver damage have not been elucidated in detail. Approach and results Based on the Korean Genome and Epidemiology Study Health Examination (KoGES_HEXA) cohort data, 21,919 participants (40‐79 years old) were included and divided into cases and controls based on the ALD diagnostic criteria proposed by the American College of Gastroenterology. Data generated by a genome wide‐association study were analyzed using logistic regression to assess the risk of ALD development in nondrinkers, light drinkers, and heavy drinkers. We detected three loci, gamma‐glu
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Minimize alcohol consumption given increased ALD risk Low
rs10024759 in ZNF827 associated with 27.3% increased alcohol-associated liver disease risk in light drinkers through telomere damage and oxidative stress.
Screening
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Liver enzyme panels (AST, ALT, GGT, ALP, bilirubin) Low
rs10024759 carriers show elevated liver enzyme levels and increased AST/ALT ratios consistent with alcohol-associated liver disease phenotype.
Consider annual baseline testing and periodic monitoring per physician guidance.