rs10024737 - HAND2-AS1, HAND2
Magnitude 2.8 · 1 study on file
Reported associations
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Ethnic similarities in genetic polymorphisms associated with atrial fibrillation: Far East Asian vs European populations. - European journal of clinical investigation (2022) · Hong M, Ebana Y, Shim J, Choi EK, Lim HE, Hwang I, Yu HT, Kim TH, Uhm JS, Joung B, Oh S, Lee MH, Kim YH, Jee SH, Pak HN · PubMed 33990960
In European ancestry, 111 genetic loci were identified as associated with atrial fibrillation (AF). We explored the reproducibility of those single nucleotide polymorphisms (SNPs) in a genome-wide association study (GWAS) meta-analysis of Far East Asian populations. We performed a meta-analysis of the Korean AF network and Japanese AF data sets (9118 cases and 33 467 controls) by an inverse-variance fixed-effects model. We compared the results with 111 previously reported SNPs proven in Europeans after excluding 36 missing loci and a locus with a minor allelic frequency (MAF) < 0.01 in the European population. Among remaining 74 loci, 29 loci were replicated at a P < .05, and 17 of those loci were newly found in the Far East Asian population: 3 loci with a P < 5×10 (METTL11B at 1q2
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic risk for atrial fibrillation and screening strategy Moderate
HAND2 variant rs10024737 C allele carriers have significantly elevated atrial fibrillation risk (p=2e-13, OR=1.33 in 42,585 subjects)
Screening
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baseline and periodic electrocardiography Moderate
HAND2-mediated atrial fibrillation risk increases susceptibility to both paroxysmal and sustained arrhythmia; baseline ECG establishes rhythm reference and detects asymptomatic arrhythmia
Baseline 12-lead ECG; discuss periodic screening intervals with cardiologist