rs10024216 - RNA5SP158 - TLR10

Magnitude 2.0 · 1 study on file

Reported associations

• Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations - Unknown journal (n.d.) · Unknown authors · PubMed 29293537

  ABSTRACT: Gene-level analysis of ImmunoChip or genome-wide association studies (GWAS) data has not been previously reported for systemic sclerosis (SSc, scleroderma). The objective of this study was to analyze genetic susceptibility loci in SSc at the gene level and to determine if the detected associations were shared in African-American and White populations, using data from ImmunoChip and GWAS genotyping studies. The White sample included 1833 cases and 3466 controls (956 cases and 2741 controls from the US and 877 cases and 725 controls from Spain) and the African American sample, 291 cases and 260 controls. In both Whites and African Americans, we performed a gene-level analysis that integrates association statistics in a gene possibly harboring multiple SNPs with weak effect on disea

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