rs10023907 - MEPE - HSP90AB3P
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 32981348
ABSTRACT: Supplemental Digital Content is available in the text. Background: Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular mortality; however, its genetic determinants remain incompletely defined. In total, 10 previously identified risk loci explain a small fraction of AAA heritability. Methods: We performed a genome-wide association study in the Million Veteran Program testing ≈18 million DNA sequence variants with AAA (7642 cases and 172 172 controls) in veterans of European ancestry with independent replication in up to 4972 cases and 99 858 controls. We then used mendelian randomization to examine the causal effects of blood pressure on AAA. We examined the association of AAA risk variants with aneurysms in the lower extremity, cerebral, and iliac arteri
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Exercise
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Regular cardiovascular exercise Low
Cardiovascular fitness reduces AAA and general vascular disease risk
Target 150 minutes moderate-intensity aerobic exercise per week
Lifestyle
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Smoking Low
Smoking greatly increases AAA risk; variant carriers already have elevated genetic risk
Cease smoking if applicable; discuss cessation strategies with healthcare provider
Screening
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Blood pressure Low
Hypertension is major modifiable AAA risk factor; variant increases baseline risk
Regular monitoring; target systolic <130 mmHg diastolic <80 mmHg
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Abdominal aortic aneurysm screening with ultrasound Moderate
Genetic variant associated with 1.09-fold increased AAA risk in large GWAS (n=179814)
Discuss with physician; typically offered to men age 65-75 or with smoking history