rs10022799 - SPOCK3

Magnitude 2.0 · 1 study on file

Reported associations

• A genome-wide association study of cognitive function in Chinese adult twins. - Biogerontology (2018) · Xu C, Zhang D, Wu Y, Tian X, Pang Z, Li S, Tan Q · PubMed 28808816

  Multiple loci or genes have been identified using genome-wide association studies mainly in western countries but with inconsistent results. No similar studies have been conducted in the world's largest and rapidly aging Chinese population. The paper aimed to identify the specific genetic variants associated with cognitive function in middle and old-aged Chinese dizygotic twins (DZ). Cognitive function was measured on 139 pairs of DZ by Montreal Cognitive Assessment. The subjects were genotyped at 1048575 SNP positions. Regression-based mixed-effect kinship model of GWAS was conducted to test the SNPs. Gene-based analysis was performed on VEGAS2. The statistically significant genes were then subject to gene set enrichment analysis to further identify the specific biological pathways associ

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