rs10021949 - GC - NPFFR2
Magnitude 2.2 · 1 study on file
Reported associations
-
Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration - Unknown journal (n.d.) · Unknown authors · PubMed 32242144
ABSTRACT: Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that 25OHD concentration has causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes have (direct or indirect) causal effects on 25OHD concentration, clarifying the epidemiological relationship between 25OHD status and the health outcomes examined in this s
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
-
vitamin D supplementation needs based on genetic variant Moderate
GC rs10021949 significantly affects vitamin D metabolism through vitamin D binding protein; physician assessment needed for genotype-specific supplementation
Screening
-
serum 25-hydroxyvitamin D levels Moderate
GC rs10021949 variant directly affects vitamin D binding protein function and serum vitamin D metabolism
annual screening or as recommended by physician