rs10019279 - LINC02500 - TENM3-AS1; LINC02500 - TENM3-AS1; LINC02500 - TENM3-AS1; LINC02500 - TENM3-AS1; LINC02500 - TENM3-AS1

Magnitude 4.5 · 1 study on file

Reported associations

• Genetic variations associated with postoperative recurrence in stage I non-small cell lung cancer. - Clinical cancer research : an official journal of the American Association for Cancer Research (2015) · Yoon KA, Jung MK, Lee D, Bae K, Joo JN, Lee GK, Lee HS, Lee JS · PubMed 24737549

  Postoperative recurrence in stage I non-small cell lung cancer (NSCLC) is the major cause of a poor prognosis. This study aims to identify genetic variants that are associated with the prognosis of early-stage NSCLCs. A genome-wide association study (GWAS) was conducted in 250 patients in stage I NSCLCs and the results were replicated in additional 308 patients. Results from an Affymetrix Genome-wide Human SNP array in 250 patients identified 94 SNPs with significant associations (P < 2 × 10(-4)), which were selected for replication in 308 additional patients. Pooled analysis of the 558 patients determined that rs1454694 in chromosome 4q34 was the most significant marker of lung cancer prognosis in the stage I patients (adjusted HR = 2.81; P = 5.91 × 10(-8)). After the candidate loci wer

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