rs10014685 - VPS51P18 - MIR548I2

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association analysis of opioid use disorder: a novel approach using clinical data - Unknown journal (n.d.) · Unknown authors · PubMed 32961455

  ABSTRACT: Background Opioid use disorder (OUD) represents a large and pervasive global public health challenge. Previous genetic studies have demonstrated the significant heritability of OUD and identified several single-nucleotide polymorphisms (SNPs) associated with its prevalence. Methods In this paper, we conducted a genome-wide association analysis on opioid use disorder that leveraged genetic and clinical data contained in a biobank of 21,310 patients of European ancestry. We identified 1,039 cases of opioid use disorder based on diagnostic codes from nearly 16 million encounters in electronic health records (EHRs). Results We discovered one novel OUD-associated locus on chromosome 4 that was significant at a genome-wide threshold (p=2.40×10−8). Heritability analysis suggested tha

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.