rs10004905 - GABRA4

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder - Unknown journal (n.d.) · Unknown authors · PubMed 36301540

  ABSTRACT: Key Points Question What is the genetic architecture of maximum habitual alcohol intake (MaxAlc), and how does it compare with other alcohol consumption measures? Findings This genetic association study of MaxAlc in 247 455 European- and African-ancestry individuals identified 15 genome-wide significant loci, including multiple novel associations. MaxAlc was genetically correlated with measures of alcohol-related problems, demonstrated significantly different correlations with psychiatric traits compared with other alcohol consumption traits, and loaded on a factor with alcohol problem traits, while alcohol consumption measures loaded on a separate factor. Meaning These findings suggest that MaxAlc is genetically different from consumption measures in relation to problematic al

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