rs10004897 - C18orf21P1 - HELQ

Magnitude 2.2 · 1 study on file

Reported associations

• Population-based genome-wide association study of cognitive decline in older adults free of dementia: Identification of a novel locus for the attention domain - Unknown journal (n.d.) · Unknown authors · PubMed 30954325

  ABSTRACT: To identify novel loci that affect cognitive decline in older adults free of dementia, we conducted genome-wide and gene-based meta-analyses on longitudinal slopes of five cognitive domains (memory, executive function, language, attention/processing speed and visuospatial ability) derived from two population-based cohorts. For decline over time in each cognitive domain, we normalized intra-individual slopes within each cohort, accounting for baseline age, sex and years of education. Normalized slope for each domain was used in cohort-specific genome-wide analyses after including top principal components as covariates followed by genome-wide and gene-based meta-analyses. Both analyses revealed a novel WDFY2 locus at genome-wide (p= 3.37E-08) and gene-wide (p= 7.10E-07) significanc

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