rs10001237 - LINC02269

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-Wide Association Study of Erosive Tooth Wear in a Finnish Cohort. - Caries research (2019) · Alaraudanjoki VK, Koivisto S, Pesonen P, Männikkö M, Leinonen J, Tjäderhane L, Laitala ML, Lussi A, Anttonen VA · PubMed 29898447

  Erosive tooth wear is defined as irreversible loss of dental tissues due to intrinsic or extrinsic acids, exacerbated by mechanical forces. Recent studies have suggested a higher prevalence of erosive tooth wear in males, as well as a genetic contribution to susceptibility to erosive tooth wear. Our aim was to examine erosive tooth wear by performing a genome-wide association study (GWAS) in a sample of the Northern Finland Birth Cohort 1966 (n = 1,962). Erosive tooth wear was assessed clinically using the basic erosive wear examination. A GWAS was performed for the whole sample as well as separately for males and females. We identified one genome-wide significant signal (rs11681214) in the GWAS of the whole sample near the genes PXDN and MYT1L. When the sample was stratified by sex, the s

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